Su Su Htwe
Singapore
Summary
Senior Post Doctoral Research Fellow at Lee Kong Chain School of Medicine, specializing in stem cell and regenerative therapies, immunology and organoid technology. Expert in high-throughput organoid development and complex cell culture systems, with a proven track record in multi-task project coordination and mentoring. Proficient in molecular biology techniques, driving innovative research outcomes.
Overview
10
10
years of professional experience
Work History
Senior Post Doctoral Research Fellow
Lee Kong Chain School of Medicine
09.2022 - Current
Company Overview: Stem Cell and Regenerative Medicine, NTU Singapore.
Project: Guided niche reconstruction for advancing the organoid system using a large-scale combinatorial screening system (iPSC-derived lung organoids).
- Optimize the high-throughput organoid screening system for small molecules and infectious screening.
- Development of a large-scale microencapsulation system (patented).
- Establishment of a high-throughput organoid sorting system with a large particle sorter.
- Maintenance and expansion of different iPSC lines.
- Multi-project management.
- Lab management.
- Presented research results at academic conferences and seminars.
- Conducted literature reviews to support ongoing research projects.
- Prepared manuscripts for publication in peer-reviewed journals.
- Constructed academic papers, reports, technical disclosures, presentations, and grants to obtain interest and funds for research studies.
- Prepared grant applications for submission to external sources seeking financial support for ongoing or upcoming initiatives associated with doctorate program.
- Academic and industrial collaboration.
- Stakeholders' meeting.
- Mentoring junior scientists, research associates, and PhD students.
Post-Doctoral Research Fellow
Bioinformatics Institute (BII)
03.2018 - 04.2022
Company Overview: Agency for Science, Technology and Research, Singapore
- Complex Cellular Phenotypic analysis group
- Project A: Development of Machine Learning Based phenotypic based assay for drug potency assessment
- Optimise the ex-vivo PDx cell model for screening.
- Expansion of different patient derived primary cell lines (with different mutations) (NSCLC lung cancer)
- Automatic handling of cell culture for high throughput applications
- Developing high throughput imaging based phenotypic profiling method to assess drug combination response.
- Project management
- Project B: Development of Transcriptomic based new approach method (NAM) for safety assessment
- Optimise cell model for potency assessment including NOAEL and LOAEL
- Maintenance and expansion of different cell lines for screening
- Transcriptomic Assay using TempO-SEQ technique
- Pathway Enrichment analysis
- Bioinformatic analysis
- Project management
- Team management
- Report deliverables
- Assisting in grant writing
- Scientific reporting
- Risk assessment
- Responsible for data and methodology sharing and progress update
- Agency for Science, Technology and Research, Singapore
Researcher
University of Nottingham
01.2015 - 12.2017
Company Overview: Division of Immunology, UK.
Project: Innovative Immunoregulatory Implant - IMMODGEL (EU-FP7 and Horizon 2020 collaborative project)
- Developed a platform with different types of topographies for the study of immunomodulation against different implanted biomaterials, with different topographies.
- Peripheral blood mononuclear cells isolation, different coculture model, immunostaining
- Expands the study on foreign body on chip (organ-on-chip) model and lung-on-chip model.
- Procurement
- GLP practice and training
- Report deliverables, Scientific reporting
- Responsible for data and methodology sharing and progress update
- Division of Immunology, UK
Education
Ph.D. - Biomedical Sciences
University of Nottingham
09-2018
MSc - Immunology and Allergy
University of Nottingham
UK01.2012
Bachelor of Medicine, Bachelor of Surgery (MBBS) -
University of Medicine 1
MyanmarSkills
Molecular and cellular biology
Cell culture techniques
- iPSC and immune cell culture
- Primary and cell line culture
- Stem cell expansion and differentiation
- Organoid development
- Complex cell culture systems
Other techniques
- Different Microscopy and imaging software
- High-throughput imaging assays
- Gene editing and transfection
- Western blotting and molecular cloning
- PCR
- scRNA-seq
- Flow cytometry analysis
- Different fluorescence and luminescence assay
- Enzyme-linked immunosorbent assay (ELISA)
- Bioinformatics and R programming
Affiliations
- Singapore Stem Cell Symposium, 2022-Present
- British Society for Immunology, 2011-2019
- IEEE Engineering in Medicine and Biology Society, 2015-2017
- American Society for Cell Biology, 2016-2017
- TERMIS, 2011-2017
- Society of Toxicology (SOT), 2019-2020
Publications
- Role of rho-associated coiled-coil forming kinase isoforms in regulation of stiffness-induced myofibroblast differentiation in lung fibrosis, American Journal of Respiratory Cell and Molecular Biology, 2017, https://www.ncbi.nlm.nih.gov/pubmed/28225294
- Investigating NF-kappaB signaling in human lung fibroblasts in 2D and 3D culture systems, Respiratory research, 2015, https://www.ncbi.nlm.nih.gov/pubmed/26619903
- A paper-based in vitro model for on-chip investigation of the human respiratory system, Lab on a Chip, 2016, https://www.ncbi.nlm.nih.gov/labs/articles/27731881
- A Foreign Body Response-on-a-Chip Platform, Adv. Healthc. Mater., 2019, https://doi.org/10.1002/adhm.201801425
- Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation, Acta biomaterialia, 2017, https://www.ncbi.nlm.nih.gov/pubmed/28159717
- Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings, Biomacromolecules, 2016, https://www.ncbi.nlm.nih.gov/pubmed/27183396
- Unbiased Analysis of the Impact of Micropatterned Biomaterials on Macrophage Behaviour Provides Insights beyond Pre-defined Polarisation States, ACS Biomaterials Science & Engineering, 2017, http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.7b00104
Awards
- 2016, Early Researcher of Excellence Award, In recognition of outstanding research contributions from University of Nottingham
- 2016, Biotech Travel Award, To attend ASCB annual meeting, San Francisco, USA
- 2015, Post Graduate Travel Award, University of Nottingham
- 2015, Young Scientist Travel Award, From 4th TERMIS World Congress, Boston, MA, USA
- 2014, Vice Chancellor Research Excellence (International) PhD Scholarship, University of Nottingham, UK
- 2014, Young Scientist Travel Award, From 9th World Congress on Alternatives and Animal Use in the Life Sciences
- 2012, Distinction in MSc Immunology and Allergy, University of Nottingham, UK
Conferences And Presentations
- A three dimensional culture system for investigating inflammatory responses in human lung, 9th World Congress on Alternatives and Animal Use in the Life Sciences, 08/01/14, Prague, Czech Republic
- Role of ROCK Isoforms in Regulation of Stiffness Induced Myofibroblast Differentiation in Lung Fibrosis, American society for cell biology meeting, 12/01/16, San Francisco, USA
- Paper-based in-vitro model for on-chip investigation of the human respiratory system, Hilton Head Workshop 2016, 06/01/16, Hilton Head, USA
Languages
English
Proficient (C2)
C2
Chinese (Mandarin)
Elementary (A2)
A2
Timeline
Senior Post Doctoral Research Fellow
Lee Kong Chain School of Medicine
09.2022 - Current
Post-Doctoral Research Fellow
Bioinformatics Institute (BII)
03.2018 - 04.2022
Researcher
University of Nottingham
01.2015 - 12.2017
Ph.D. - Biomedical Sciences
University of Nottingham
MSc - Immunology and Allergy
University of Nottingham
Bachelor of Medicine, Bachelor of Surgery (MBBS) -
University of Medicine 1
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