Sugumaran Praveen Kumar

Summary

Experienced professional with a strong background in research and quality control, supported by 6 years of dedicated research and 5 years of industry quality control lab experience. Proficient in working with multiple regulatory bodies, including EPA, APHA, and EMEA, ensuring rigorous adherence to quality standards. Seeking a challenging role in drug formulation and delivery as part of a dynamic team. Proven ability to collaborate with drug formulation experts, scientific thought leaders, and R&D teams to develop innovative drug and excipient-based molecule.

Overview

years of professional experience

Work History

Laboratory Manager

Tribocare Pte Ltd

02.2019 - 07.2023

Kept laboratory in compliance with applicable guidelines and laws.
Made recommendations for adjustments to processes and procedures related to laboratory testing and compliance consistent with ISO/IEC 17025 standards.
Set and oversaw quality assurance guidelines for laboratory work.
Analyze marine water and environmental samples for chemical and biological parameters, including Biochemical Oxygen Demand, Total Suspended Solids, Chemical Oxygen Demand, Chlorides, Phosphorus, Microbiological Analysis as per EPA, APHA, ISO standards Methods.

Senior Executive

CURA TEQ Biologicals

06.2016 - 05.2017

Responsible for in- process, finished product and water samples (USP, WFI, process water, and feed water) quality control testing .
Used GLPs, SOPs, processes, and company policies when performing all quality control job functions.
Prepared summary report for laboratory analysis of quality control testing.
Assisted with aseptic sampling collection, monitoring procedures, and maintaining sample collection for quality control testing.

Education

Ph.D. - Biotechnology

Anna University

India

08.2018

Master of Science - Industrial Pharmaceutical Science

Annamalai University

India

04.2007

Skills

Formulation Development: Pharmaceutical formulation techniques and experience in optimizing drug delivery systems
Pharmacology: In-depth understanding of drug pharmacology, including mechanisms of action, pharmacokinetics, and pharmacodynamics
Pre-Clinical Testing: Experience in designing and conducting pre-clinical studies, including in vitro and in vivo experiments

Analytical Techniques: Proficiency in various analytical techniques such as Ionization Chromatography, ICP, and spectroscopy for drug characterization
Molecular Biological assay Techniques
GMP/GCP: Knowledge of Good Manufacturing Practices (GMP) and Good Clinical Practices (GCP) to ensure product quality and ethical conduct in clinical trials

Accomplishments

Amitriptyline, 3(10,11-dihydro-5H-dibenzo (a,d) cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine, newer class of selective serotonin reuptake inhibitors (SSRIs). Sustained release (SR) dosage forms release a drug at a predetermined rate to maintain a constant drug concentration in the systemic circulation for an extended period. AMT was formulated with different compositions of the polymer hydroxypropyl methylcellulose (HPMC) K100M to increase SR delivery of the drug in the GI tract and consequently into systemic circulation. Using a wet granulation method, AMT, and various compositions of HPMC K100M were mixed and compressed into tablets using an automatic rotary tablet press. The release of the drug from the tablets was measured using an in vitro dissolution method (USP). The final formulation released 98.95% of the drug in 45 minutes and 97.40% of the drug in 12 hours.

Additional Information

Research Project:

20-HETE, a signalling molecule produced by CYP4A1 from arachidonic acid. 20-HETE is involved in a variety of physiological and pathological processes, including apoptosis, vascular tone, inflammation, and cell growth. Developing drugs that target 20-HETE signalling as potential treatments for these diseases. Pulmonary endothelial cells anti-apoptotic effects of 20-HETE are mediated through signalling pathways including MAPK and PI3K/Akt, as well as through eNOS uncoupling and NOX/ROS production.

Timeline