Zbynek Bozdech

Innovative scientist and academic bringing over 20-year background instructing students. Expertise in classroom oversight, course planning and behavior management. Successful at collaborating with teachers, administrative leaders and support specialists to meet individual student needs. Committed to encouraging higher-order thinking to increase student performance.

• Open Fund Individual Research Grant, National Medical Research Council (NMRC), Singapore, 2022, S$ 1,243,000.00, 4 years
• Academic Research Council Tier2 grant, Ministry of Education (MOE) of Singapore, 2020, S$ 881,220.00, 3 years
• National Research foundation, Singapore, Discovering New Target Space for the Development of Drugs Against Malaria Parasites, ongoing, S$ $10,360,600.00, 5 years
• Academic Research Council Tier3 grant, MOE of Singapore, 2020, S$8,539,576.00, 5 years
• Academic Research Council Tier2 grant, MOE of Singapore, 2018, S$ 994,103.60, 3 years
• Open Fund Individual Research Grant, National Medical Research Council (NMRC), Singapore, 2017, S$ 1,303,473.67, 3 years
• Ministry of Heath, Singapore, CAT2, Establishing A Proteome-Wide Drug Interaction MS-CETSA Platform At NTU@Biopolis, 2015, S$ 2,965,600, 3 years
• Department of International Development (DIFID, UK), Understanding Of Molecular Mechanisms Of Drug Resistance In Malaria Parasites, P. Falciparum Transcriptomic Analyses Of TRACII Samples, 2017, S$ 162,042.96, 1 year
• National Health and Medical Research Council, Australia, Targeting commitment to sexual differentiation in Plasmodium, 2016-2018, AUS$688,954

• Annual meetings of the American Society of Tropical medicine and Hygiene, USA, 2010, 2012, 2014, 2016, 2018, 2020, 2022, invited session speaker
• Annual BioMalPar / EVIMalaR Conference, Heidelberg, Germany, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, invited keynote speaker (2014), selected oral presentation
• Molecular approaches to malaria (MAM), Lorne, VIC, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2022, selected oral presentations, session chair
• Genomic Epidemiology of Malaria, Hinxton, Cambridge, 2012, 2014, 2016, 2018, invited session speaker
• International Congress in Parasitology, Mexico City, 2014, invited keynote speaker at the former president’s session
• Joint International Tropical Medicine Meeting, Bangkok, Thailand, 2017, invited speaker
• Singapore International Infectious Disease Conference (SIIDC), Singapore, 2017, invited session chair
• EMBO workshop, Systems biology of infectious diseases, Singapore, 2018, invited speaker
• 2nd biannual PARAFRAP conference, Les Embiez, France, 2016, session chair
• 9th European Congress on Tropical Medicine and International Health, Basel, Switzerland, 2015, invited keynote speaker
• Infectious Disease Genomics meeting, Hinxton, Cambridge, 2015, Invited speaker/session chair
• 5th International Conference for Plasmodium vivax Research, Bali, 2015, Invited keynote speaker/workshop organizer

• 2021, Member of the editorial board of the Malaria Journal (BMC, Springer Nature FI=2.979).
• 2018, President of Singapore Malaria Network (SingMalNet) society, Singapore
• 2018, Co-Investigator on an international study of deployment of malaria triple combination therapies (DeTACT), coordinated by Oxford University, UK.
• 2015 - 2018, Co-Investigator on an international study of artemisinin resistance “Tracking Resistance to Artemisinin II (TRACII)” coordinated by Oxford University, UK.
• 2011 - 2014, Co-Investigator on an international study of artemisinin resistance “Tracking Resistance to Artemisinin (TRAC)” coordinated by Oxford University, UK.

• Jaishree Tripathi, L. Z., Sourav Nayak, Michal Stoklasa, Zbynek Bozdech. Stochastic Expression of Invasion Genes in Plasmodium falciparum Schizonts. Nature Communications. 2022 May 30;13(1):3004.
• Grennady Wirjanata, J. M. D., Jianqing Lin, Abbas El Sahili, … Pär Nordlund, Julien Lescar, Zbynek Bozdech. Identification of an inhibitory pocket in falcilysin bound by chloroquine provides a new avenue for malaria drug development. (2022).
• Lei Zhu, R. W. v. d. P., Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Nosten, … Nicholas PJ Day, Nicholas J. White, Arjen M Dondorp, Zbynek Bozdech. The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response. Communication Biology 2022 Mar 28;5(1):274.
• Matthias Paulus Wagner, Pauline Formaglio, Olivier Gorgette, Jerzy Michal Dziekan, Christèle … Zbynek Bozdech, Rogerio Amino, Lhousseine Touqui, Chetan E. Chitnis, Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target, Cell Reports, Jun 14;39(11):110923.
• Reverse transcription PCR to detect low density malaria infections. Christensen P, Bozdech Z, Watthanaworawit W, Rénia L, Malleret B, Ling C, Nosten F. Wellcome Open Res. 2021 Aug 4;6:39.
• Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates with Evolutionarily Novel Subunits. Iyer UB, Park JE, Sze SK, Bozdech Z, Featherstone M. ACS Omega. 2022 Apr 20;7(17):14867-14874.
• Tinto-Font, E., Michel-Todo, L., Russell, T. J., Casas-Vila, N., Conway, D. J., Bozdech, Z., Llinas, M. & Cortes, A. A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures. Nat Microbiol 6, 1163-1174, (2021).
• Paolo Mesén-Ramírez, B. B., Mourad Elhabiri, Lei Zhu, Heidrun von Thien, Carolina Castro-Peña, Tim-Wolf Gilberger, Elisabeth Davioud-Charvet, Zbynek Bozdech, Anna Bachmann, Tobias Spielmann. The parasitophorous vacuole nutrient pore is critical for drug access in malaria parasites and modulates the fitness cost of artemisinin resistance. Cell Host and Microbe, Volume 29, Issue 12, 1774-1787.e9 (2021).
• Mok, S., Stokes, B. H., Gnadig, N. F., Ross, L. S., Yeo, T., Amaratunga, C., Allman, E., Solyakov, L., Bottrill, A. R., Tripathi, J., Fairhurst, R. M., Llinas, M., Bozdech, Z., Tobin, A. B. & Fidock, D. A. Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival. Nat Commun 12, 530, (2021).
• Patra, A. T., Hingamire, T., Belekar, M. A., Xiong, A., Subramanian, G., Bozdech, Z., Preiser, P., Shanmugam, D. & Chandramohanadas, R. Whole-Cell Phenotypic Screening of Medicines for Malaria Venture Pathogen Box Identifies Specific Inhibitors of Plasmodium falciparum Late-Stage Development and Egress. Antimicrob Agents Chemother 64, (2020).
• Kucharski, M., Tripathi, J., Nayak, S., Zhu, L., Wirjanata, G., van der Pluijm, R. W., Dhorda, M., Dondorp, A. & Bozdech, Z. A comprehensive RNA handling and transcriptomics guide for high-throughput processing of Plasmodium blood-stage samples. Malar J 19, 363, (2020).
• Dziekan, J. M., Wirjanata, G., Dai, L., Go, K. D., Yu, H., Lim, Y. T., Chen, L., Wang, L. C., Puspita, B., Prabhu, N., Sobota, R. M., Nordlund, P. & Bozdech, Z. Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome. Nat Protoc 15, 1881-1921, (2020).
• Dziekan, J. M., Yu, H., Chen, D., Dai, L., Wirjanata, G., Larsson, A., Prabhu, N., Sobota, R. M., Bozdech, Z. & Nordlund, P. Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay. Sci Transl Med 11, (2019).
• Zhu, L., Tripathi, J., Rocamora, F. M., Miotto, O., van der Pluijm, R., Voss, T. S., Mok, S., Kwiatkowski, D. P., Nosten, F., Day, N. P. J., White, N. J., Dondorp, A. M., Bozdech, Z. & Tracking Resistance to Artemisinin Collaboration, I. The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background. Nat Commun 9, 5158, (2018).
• Ashley, E. A., Dhorda, M., … Kwiatkowski, D. P., Bozdech, Z., … Dondorp, A. M., Day, N. P., White, N. J. & Tracking Resistance to Artemisinin, C. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 371, 411-423, (2014).
• Hu, G., Cabrera, A., Kono, M., Mok, S., Chaal, B. K., Haase, S., Engelberg, K., Cheemadan, S., Spielmann, T., Preiser, P. R., Gilberger, T. W. & Bozdech, Z. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol 28, 91-98, (2010).
• Bozdech, Z., Mok, S., Hu, G., Imwong, M., Jaidee, A., Russell, B., Ginsburg, H., Nosten, F., Day, N. P., White, N. J., Carlton, J. M. & Preiser, P. R. The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Proc Natl Acad Sci U S A 105, 16290-16295, (2008).
• Bozdech, Z., Llinas, M., Pulliam, B. L., Wong, E. D., Zhu, J. & DeRisi, J. L. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 1, E5, (2003).