Ting Gan
Singapore
Summary
Technician / Mass Spectrometry Analyst
Overview
3
3
years of professional experience
Work History
Protein Quality Control Researcher
GenScript Biotech Corporation
10.2023 - Current
- - Performed LC-MS and LC-MS/MS for peptide mapping, PTM identification, molecular weight confirmation, and structural integrity assessment.
- - Utilized TOF and Q-TOF platforms with UNIFI and MassHunter Qualitative Analysis software to identify glycosylation, oxidation, and other modification sites in antibodies and proteins.
- - Conducted structural analysis, sequence alignment, and modification identification using Expasy, Uniprot, PDB, and CLUSTALW.
- - Established antibody fragmentation workflows using IdeS and IdeZ enzymatic digestion (Fc/2 + F(ab')₂).
- - Performed protein structural and glycosylation analysis using Glyserias enzyme digestion, assessing conformational stability.
- - Evaluated protein main peaks and isoforms using Intact Mass and SEC-HPLC to monitor aggregate content and stability.
- - Provided analytical support for multiple antibody/recombinant protein drug development projects and progress reports.
- - Skilled in HPLC, UPLC, ELISA, SDS-PAGE, CE-SDS, and Western blot.
- - Assisted in method validation, SOP revisions, and lab compliance with data traceability standards.
Protein Analysis Researcher
WuXi Biologics
08.2022 - 09.2023
- - Expert in LC-MS/MS for primary structure confirmation, PTM analysis, and glycan profiling.
- - Performed reduction and enzymatic digestion of monoclonal antibodies, achieving >80% sequence coverage.
- - Analyzed glycan distribution using PNGase F digestion coupled with LC-MS.
- - Operated Titer (affinity chromatography), HPLC, and performed routine column maintenance.
- - Independently managed client projects, including sample testing, data analysis, and report generation.
Education
Master of Science - Food Science and Engineering
Nanchang University
06.2022
Bachelor of Engineering - Bioengineering
Nanchang University
06.2019
Skills
- - Instruments & Techniques: LC-MS/MS, HPLC/UPLC, SDS-PAGE, CE-SDS, ELISA, Western Blot, PCR, Cell Culture, RNA Extraction
- - Software: Empower, Chromeleon, UNIFI, MassHunter, GraphPad Prism, ClustalW, Expasy, UniProt
- - Expertise: Protein digestion and modification analysis, mAb structure confirmation, glycosylation profiling, antibody fragmentation, structural variant assessment
Timeline
Protein Quality Control Researcher
GenScript Biotech Corporation
10.2023 - Current
Protein Analysis Researcher
WuXi Biologics
08.2022 - 09.2023
Bachelor of Engineering - Bioengineering
Nanchang University
Master of Science - Food Science and Engineering
Nanchang University
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