PAOLO ALBERTO LORENZINI
Senior Scientist
Overview
17
17
years of professional experience
10
10
years of post-secondary education
6
6
Certifications
Work History
Senior Scientist (Bioinformatics)
Agency for Science, Technology and Research (A*STAR)
06.2023 - Current
- Company Overview: Employed under Infectious Disease Labs (IDLabs) Antiviral Therapeutics.
- Adjunct role at the Bioinformatics Institute (BII) Protein Analysis
Research Fellow (Bioinformatics)
Lee Kong Chian (LKC) School of Medicine, Nanyang Technological University (NTU) and Imperial College, London
07.2021 - 06.2023
- Company Overview: Employed under the Computational Biology Unit (https://www.healthforlife.sg/).
- Employed under the Computational Biology Unit (https://www.healthforlife.sg/).
Research Fellow (Bioinformatics)
Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
10.2020 - 06.2021
- Company Overview: Employed under the Single Cell Spatial Transcriptomics Unit.
- Employed under the Single Cell Spatial Transcriptomics Unit.
Research Fellow (Bioinformatics)
Asian School of Environment (ASE), Nanyang Technological University (NTU)
06.2018 - 10.2020
- Company Overview: Employed under GenomeAsia100K consortium (https://genomeasia100k.org).
- Employed under GenomeAsia100K consortium (https://genomeasia100k.org).
Research Assistant
Department of Paediatrics, National University of Singapore (NUS)
09.2012 - 12.2013
Research Assistant
Department of Physiology, National University of Singapore (NUS)
10.2011 - 08.2012
Research Assistant
Cancer Science Institute of Singapore (CSI), National University of Singapore (NUS)
11.2010 - 10.2011
Research Assistant
School of Biological Sciences, Nanyang Technological University (NTU)
11.2009 - 10.2010
Laboratory Technician
Department of Infectious Diseases, San Raffaele Institute
01.2008 - 12.2008
Education
Doctor of Philosophy (Ph.D.) - Molecular and Computational Biology
Nanyang Technological University (NTU)
01.2014 - 04.2018
Master Degree (M.Sc.) - Biotechnology
University of Pavia
12.2005 - 10.2007
Bachelor’s Degree (B.Sc.) - Chemistry
University of Pavia
10.2001 - 12.2005
Skills
- R
- Python
- Matlab
- Perl
- Bash
- Github
- Anaconda
- AWS
- cluster supercomputer HPC
- data analysis
- omics data integration
- Genotyping
- Whole Genome Sequencing (WGS)
- bulk RNA-seq
- single cell RNA-seq
- spatial transcriptomics (MERFISH)
- ATAC-seq
- CHIP-seq
- metabolomics
- proteomics
- molecular docking
- AI for drug discovery
- CNNs
- GNNs
- SVMs
Certification
Professional Certificate in Python (Simplilearn)
Expertise
R, Python, Matlab, Perl, Bash, Github, Anaconda, AWS, cluster supercomputer HPC, Genotyping, Whole Genome Sequencing (WGS), bulk RNA-seq, single cell RNA-seq, spatial transcriptomics (MERFISH), ATAC-seq, CHIP-seq, metabolomics, proteomics, AI for drug discovery (CNNs, GNNs, SVMs, LGBMs, KNNs, RF, Generative AI), MDS, Word, Excel, Powerpoint, Tableaux, Illustrator
Grants
Wuxi Grant call 2025, In silico design of small molecules targeting the ABM fungal protein to stimulate plant immune response
Personal Information
- Citizenship: Italian (EU passport holder)
- Date of Birth: 04/26/82
- Marital Status: Single
Publications
- Soy lecithin strengthens amaranth protein-based omelettes through protein complexation which alters protein interactions, Uma Jingxin Tay, Joanne Yi Hui Toy, Chengxin He, Marco Vignuzzi, Xin Yang, Gomathy Sandhya Subramanian, Maria Antipina, Paolo Alberto Lorenzini, Weibiao Zhou, Dejian Huang, 2025, Food Structure
- Multi-omics and Mendelian Randomization network analysis of the association between metabolic and cognitive functions in the UK Biobank Database, Lorenzini, P. A., S. R. Langley, 2024, medRxiv
- Population-specific positive selection on low CR1 expression in malaria endemic regions, Paolo Alberto Lorenzini, Elena S. Gusareva, Amit Gourav Ghosh, Nurul Adilah Binte Ramli, Hie Lim Kim, 2023, PLOS One
- Population-specific adaptation in malaria-endemic regions of Asia, Elena S. Gusareva, Paolo Alberto Lorenzini
- Nurul Adilah Binte Ramli, Amit Gourav Ghosh, Hie Lim Kim, 2021, Journal of Bioinformatics and Computational Biology (Special Issue)
- Coauthor
- Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature, Paolo Alberto Lorenzini, Resilind Su Ern Chew, Cheryl Weiqi Tan, Jing Yen Yong, Fan Zhang, Jie Zheng, Xavier Roca, 2019, RNA
- Vitamin D increases human TLR9 response against Mycobacterium tuberculosis DNA from different lineages, Jorge L. Cervantes, Esther Oak, John Garcia, Liu Hongfei, Paolo A. Lorenzini, Deepika Batra, Arvind Chhabra, Juan Salazar, Xavier Roca, 2019, Tuberculosis
- Global analysis of alternative splicing during human monocyte differentiation to macrophage and their inflammatory activation reveals MBNL1 as major regulator, Hongfei Liu, Paolo Alberto Lorenzini, Fan Zhang, Shaohi Xu, Mei Su Michelle Wong, Jie Zheng, Xavier Roca, 2018, Nucleic Acids Research
- T Lymphocytes Expressing a CD16 Signalling Receptor Exert Antibody-Dependent Cancer Cell Killing, Ko Kudo, Chihaya Imai, Paolo Lorenzini, Takahiro Kamiya, Koji Kono, Andrew M. Davidoff, Wee Joo Chng, Dario Campana, 2013, Cancer Research
- Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signalling, Moh MC, Lorenzini PA, Gullo C, Schwarz H, 2013, Faseb
Timeline
Senior Scientist (Bioinformatics)
Agency for Science, Technology and Research (A*STAR)
06.2023 - Current
Research Fellow (Bioinformatics)
Lee Kong Chian (LKC) School of Medicine, Nanyang Technological University (NTU) and Imperial College, London
07.2021 - 06.2023
Research Fellow (Bioinformatics)
Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
10.2020 - 06.2021
Research Fellow (Bioinformatics)
Asian School of Environment (ASE), Nanyang Technological University (NTU)
06.2018 - 10.2020
Doctor of Philosophy (Ph.D.) - Molecular and Computational Biology
Nanyang Technological University (NTU)
01.2014 - 04.2018
Research Assistant
Department of Paediatrics, National University of Singapore (NUS)
09.2012 - 12.2013
Research Assistant
Department of Physiology, National University of Singapore (NUS)
10.2011 - 08.2012
Research Assistant
Cancer Science Institute of Singapore (CSI), National University of Singapore (NUS)
11.2010 - 10.2011
Research Assistant
School of Biological Sciences, Nanyang Technological University (NTU)
11.2009 - 10.2010
Laboratory Technician
Department of Infectious Diseases, San Raffaele Institute
01.2008 - 12.2008
Master Degree (M.Sc.) - Biotechnology
University of Pavia
12.2005 - 10.2007
Bachelor’s Degree (B.Sc.) - Chemistry
University of Pavia
10.2001 - 12.2005
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