Ghim Hoe Ho

Dynamic Research Officer at the National Neuroscience Institute, skilled in Drosophila work studies, data collection and qualitative research.

Proven ability to analyze research results and evaluate programs effectively. Recognized for enhancing research methodologies, leading to significant improvements in project outcomes. Strong communicator with a commitment to advancing neuroscience through innovative research practices.

Publications

1)Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect.(2009)

2)Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.(2010)

3)Analysis of EIF4G1 in Parkinson's disease among Asians.(2012)

4)Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.(2013)

5)In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila.(2014)

6)Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila.(2014)

7)F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy.(2015)

8)Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2.(2016)

9)Varied pathological and therapeutic response effects associated with CHCHD2 mutant and risk variants.(2017)

10)The Therapeutic Implications of Tea Polyphenols Against Dopamine (DA) Neuron Degeneration in Parkinson's Disease (PD).(2019)

11)Chetomin rescues pathogenic phenotype of LRRK2 mutation in drosophila. (2022)

12)Identification of Targets from LRRK2 Rescue Phenotypes.(2021)

13)The role of tyrosine hydroxylase-dopamine pathway in Parkinson's disease pathogenesis. (2022)